mRNA Pilot Plant lab- Team Associate II

Yoh presents an excellent long-term mRNA Pilot Plant Associate opportunity with a trusted client located in Waltham, MA. The client is seeking a highly motivated and scientifically rigorous individual to join the Plasmid Production Pilot team. You will focus on execution and scale-up of a robust pDNA production process focusing on bacterial cell lysis, supercoiled plasmid DNA linearization, and purification for preclinical linearized plasmid DNA production, with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for mRNA drug substance with applications towards vaccine development.
 

• Evaluate, and implement purification technology and optimize existing techniques and workflows.
• Support the execution and optimization of plasmid DNA purification, problem solving.
• Design and execute decision-quality research; prepare/draft SOPs, technical reports, batch record, and presentations to management and other stakeholders.
• Work independently, pro-actively, and be an impactful contributor to project teams. Function in highly collaborative cross functional teams.
• Execute ~20 batches per year.
• This will be primarily a lab-based position.

Qualifications

• BS with 1-3 years or MS with 0-2 years of relevant industrial experience in a related field (e.g. biochemistry, chemistry, chemical or biomedical engineering) for Senior Research Associate role.
• Demonstrated hands-on experience in small and large scale plasmid DNA extraction and purification methodologies including alkali lysis, chromatography separation (anion exchange, hydrophobic interaction) and buffer exchange methods. Familiar with Cytiva AKTA Pilot and Ready system and Repligen TFF system (K2Ri and KMPi) are preferred.
• Prepare buffers for purification process.
• Familiar with equipment setup, process troubleshooting and maintenance and experience in GLP environment is advantageous.
• Works collaboratively within group for improved operational excellence as well as within interdisciplinary teams.
• Desire to work in a team-first, fast-paced environment, learn new technologies and skills, and to efficiently solve problems.
• Excellent organizational and communication skills.
• Attention to detail & meticulous record keeping.
• Demonstrate continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team, and company

Estimated Min Rate: $21.00
Estimated Max Rate: $30.00


What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
• Health Savings Account (HSA) (for employees working 20+ hours per week)
• Life & Disability Insurance (for employees working 20+ hours per week)
• MetLife Voluntary Benefits
• Employee Assistance Program (EAP)
• 401K Retirement Savings Plan
• Direct Deposit & weekly epayroll
• Referral Bonus Programs
• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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