Scientist - II

Scientist, Histology and Spatial Biology
Job Description
We are seeking an experienced scientist with deep, hands-on expertise in histology and antibody validation to join a fast-paced and highly collaborative scientific environment. This role will support multiple ongoing spatial omics projects including biomarker discovery and target validation initiatives requiring someone who is highly adaptable, detail-oriented, and comfortable balancing planned work with urgent, short-term requests. The ideal candidate thrives in a dynamic environment, approaches shifting priorities as an opportunity, and can deliver high-quality work across a broad range of histology and multiplex imaging workflows.

Key Responsibilities

• Contribute to and help shape DAGS multiomics and spatial biology experimental strategies.
• Support the maintenance, troubleshooting, and optimization of histology instruments and associated laboratory workflows. Maintain, calibrate, and document the use of laboratory equipment in compliance with internal standards.
• Perform routine and advanced preparation of histological slides from FFPE blocks, including embedding, sectioning, staining, labeling, and quality assessment.
• Perform antibody validation using chromogenic and multiplex immunofluorescence approaches to support assay development and target validation.
• Design, optimize, and validate multiplex immunofluorescence panels using the Lunaphore COMET platform and execute assigned projects with accuracy and timeliness.
• Collaborate with cross-functional and cross-departmental teams to support target evaluation, assay troubleshooting, and technology implementation.
• Manage multiple priorities effectively in a fast-paced setting while maintaining scientific rigor and attention to detail.
• Contribute ideas for workflow improvements, assay optimization, and adoption of Client technologies.

Essential Requirements

• BS with 6years or M.Sc. with 4years or PHD with 2years in a relevant scientific discipline with significant hands-on experience in histological techniques.
• Demonstrated expertise in antibody validation using chromogenic and multiplex immunofluorescence staining methods.
• Familiarity with automated staining platforms, preferably the Leica BOND system.
• Strong experience in high-plex spatial biology and multiplex immunofluorescence methodologies, including platforms such as Lunaphore COMET, CODEX, CellScape, and imaging mass cytometry.
• Experience operating microscopy systems and modern slide scanners such as Leica GT450, Akoya PhenoImager, or Zeiss Axioscan.
• Proficiency with image visualization and analysis software, such as HALO, QuPath, and ImageJ.
• Strong scientific judgment, critical thinking, and problem-solving skills.
• Excellent communication and collaboration skills, with the ability to work effectively across teams.
• Curiosity, adaptability, and a proactive mindset toward learning and implementing new technologies.

Preferred Qualifications

• Experience with assay development, optimization, and troubleshooting in a research or translational setting.
• Familiarity with tissue biomarker evaluation, spatial tissue profiling, or pathology-adjacent workflows.
• Experience documenting and standardizing workflows, SOPs, and QC procedures.
• Ability to independently prioritize requests and manage multiple concurrent projects.
• Demonstrated experience working in a matrixed, interdisciplinary environment.
• Exposure to data interpretation and presentation of histology or imaging-based results to scientific stakeholders.

Nesco Resource offers a comprehensive benefits package for our associates, which includes a MEC (Minimum Essential Coverage) plan that encompasses Medical, Vision, Dental, 401K, and EAP (Employee Assistance Program) services.

Nesco Resource provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.